Download scientific diagram | – Cnidoscolus quercifolius plant. from publication: Análise Química e Bromatológica da Forragem da Faveleira (Cnidoscolus. PDF | Objective: To evaluate the chemical components of active extract from Cnidoscolus quercifolius root bark and its cytotoxic potential. The Cnidoscolus quercifolius (Pohl) popularly known as “favela” or “faveleira” is a forager that is part of the native species from the caatinga.

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In a study conducted with the oil from the seeds and extract from the leaves of the faveleira, Ribeiro [ 45 ] found reduced mycelial growth and germination of conidia of F. There was no inhibitory response from the extracts tested against Escherichia coli and Klebsiella pneumoniae strains, thus demonstrating that the methanolic extracts of faveleira showed better inhibition against strains of Gram-positive bacteria.

In the analysis of the leaves of C. The inhibition was indicated by the presence of white halos. Among these is the faveleiraused in northeastern Brazil. The querdifolius demonstrated great potential as an antimicrobial agent, an important antioxidant capacity, and acetylcholinesterase inhibition response with no significant difference compared with the reference drug.

The determination of the Minimum Inhibitory Concentration of Fungi MIC-f was obtained with a stereoscope, verifying the lower concentration of samples capable of inhibiting the growth of the microorganism, after 5 days of incubation. The present study, of crude methanolic extracts of Cnidoscolus quercifolius Cnidscolus, has shown promising results in all tests performed.

The bioautography method employing Ellman reagent allows for the identification of compounds capable of inhibiting acetylcholinesterase AChE in extracts, which enables a fractionation targeted to the isolation of those compounds.

Screening of Bioactivities and Toxicity of Cnidoscolus quercifolius Pohl

View at Google Scholar J. Peixoto Sobrinho et al. Table of Contents Alerts. One of the first AChE inhibitors used was physostigmine, an alkaloid isolated from a plant of the Leguminosae family, although this alkaloid is no longer used clinically, due to its short half-life. Spreading across an area of approximately thousand square km, the caatinga, an exclusively Brazilian biome, is also one of the most endangered areas in the planet. Result of inhibition of the acetylcholinesterase enzyme from methanolic extracts of C.

Despite this unique condition, there was not enough incentive to direct local preservation botanical studies [ 8 ]. Indexed in Science Citation Index Expanded. All the methanolic extracts of the faveleira presented anticholinesterase activity.


In performing the inhibition test of fungal growth, it was observed that the LME showed inhibition against Lasiodiplodia theobromae LF11, L. Materials and Methods 2.

The use of less complex animal organisms, as is the case of Artemia salinacan be done to evaluate the toxicity of bioactive compounds, besides being a simple, fast, and low-cost test. Then they performed a serial dilution of 2, at 4. Advanced Search Users Online: Today, according to Amorozo [ 2 ], the introduction of modern medicine offers another option for health practices in traditional communities that use popular medicine.

Table 2 shows the results of antimicrobial cndioscolus of methanolic extracts of C. It stands out for its extraordinary drought resistance and medicinal properties. View at Google Scholar I.

Preliminary Cnkdoscolus Analysis The extracts were subjected to phytochemical screening, following the protocols described by Mattos [ 16 ]. The halos were measured and compared with the halo formed by physostigmine, a standard alkaloid.

In many cases, the procedures of modern medicine and popular medicine are supplemental and constitute an effective form of primary health care, which may supplement the treatment usually employed in the lower income population.

In the agar diffusion method, the extracts showed activity against strains of Staphylococcus and E. Antioxidant Activity The in vitro antioxidant activity of the extracts was determined using the 1,1-diphenylpicrylhydrazyl DPPH method, querciolius previously reported by Brand-Williams et al.

The methodology began with the collection and herborization of the plant material, to obtain the chemical compounds, preliminary phytochemical analysis, and extraction of the constituents of the active extracts. Da Planta ao MedicamentoC. To evaluate the chemical components of active extract from Cnidoscolus quercifolius root bark and its cytotoxic potential against several tumor strains.

Studies have shown that plants used in traditional medicine have the effect of prevention and protection under conditions of oxidative stress [ 38 — 40 ]. According to Ribeiro and Brito [ 15 ], the faveleira can be used for forestation, recovery of degraded areas, animal and human consumption, medicine, timber, and energy.

In Brazil, the first Europeans who settled in the land ran across a large quantity of medicinal plants used by the indigenous populations who lived here.

Cnidoscolus quercifolius – Useful Tropical Plants

The in vitro cytotoxic activity of methanol extract on human colon cancer cell lines was evaluated using OVCAR-8, SF, HCT, HL strains and the samples were assessed by 3- 4,5-dimethylthiazol2-yl -2,5-diphenyltetrazolium bromide method. Studies conducted by Almeida and Amorim [ 36 ] showed that the methanolic extract of the root of C. Preliminary phytochemical analysis of C.


Souza [ 55 ] describes that the absence of toxicity can be an advantage for the possibility of using isolated substances in developing herbal medicines for use in humans.

Thus, when there is presence of active antioxidant compounds within these systems, they are capable of stabilizing or deactivate free radicals before they strike the biological targets in the cells [ 34 ].

Evidence-Based Complementary and Alternative Medicine

The high-performance liquid chromatography with diode-array detection and 1 H and 13 C nuclear magnetic resonance spectroscopy of the extract were used to distinguish the existence of possible functional groups in the root bark extract. This is a different outcome from the findings of this study, for none of the methanolic extracts of the faveleira exhibited growth inhibition of fungi of the same family.

Cnidosdolus the evaluation of toxicity of methanolic extracts of C. Several authors call attention to the direct dependency on this environmental resource by the populations living out of extractivist activities within the biome [ 910 ]. Antimicrobial assays against bacterial strains and fungi tested, using commercial drugs Chloramphenicol, Streptomycin, and Thiabendazole as a positive control, showed no growth of microorganisms.

Almeida [ 43 ] performed an antimicrobial assay with strains of bacteria and fungi using hydroalcoholic extract of the leaves of C. Despite the negative presence of alkaloids in the faveleira extracts tested, the plant presented satisfactory activity of enzyme inhibition, when compared wuercifolius the reference substance, raising the possibility that new untested substances may act on the inhibition of AChE.

This difference in the presence and absence of certain chemical compounds of plant species may be related to factors such as age of the plant and the time of collection cnjdoscolus 31 ]. Hoffm presented relevant antioxidant activity and phenolic compounds in the species, suggesting that C.